Endocrine Abstracts

Background: Cystic fibrosis-related bone disease (CFBD) is an emerging complication of cystic fibrosis (CF), especially in CF-lung transplant candidates for end-stage disease.Objectives: The assessment of vitamin D levels, bone mineral density (BMD) and morphometric and clinical prevalent fragility fractures in a cohort of young adults affected with CF awaiting lung transplantation for end-stage respiratory failure.Methods: In 42 C...

It has been suggested that the selective m-TOR inhibitor, Rapamycin, has been improved the success pancreatic islet allotransplantation (ITx) in type 1 diabetic patients (T1DM). Forty-one ITx were studied. Thirteen T1DM in poor glycemic control underwent a 45-days Rapamycin before ITx followed by standard Edmonton Protocol (EP, group 1, Milan), and they were compared to 28 T1DM patients undergoing EP (group 2, Miami). Outcome measures were daily insulin requirement (DIR), HbA1...

Introduction: Bone marrow fat is considered a risk factor for osteoporosis and fragility fracture. It is not clear if bone marrow adiposity is increased in obesity and how it relates to other compartments of adipose tissue, in particular visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and epicardial adipose tissue (EAT).Aim: To evaluate bone marrow adiposity in obese as compared with normal weight women.Design: Tw...